Specialized Pro-Resolving Mediators (SPMs): An Unexpected Hero for Inflammation
Specialized Pro-Resolving Mediators (SPMs) are lipid mediators (or bioactive lipids that communicate with our cells). In this way, they help reduce inflammation at the cellular level. While new types of SPMs are still being discovered, the ones already known are powerful inflammation-fighting agents.
What’s fascinating about SPMs is that they target immune cells, modifying their behavior rather than completely blocking inflammation.
Although SPMs are naturally produced by the body, their precursors—omega-3 fatty acids—cannot be synthesized by the body. This is why it is important to choose a high-quality SPM supplement and consume foods rich in seafood.
What Does SPM Mean?
SPMs are important fat molecules involved in the adjustment of inflammation, due to the highly potent (pn-ng) range endogenous signaling metabolites from Omega-3 polyunsaturated fatty acids (PUFA). They function by reducing excessive inflammatory responses after an acute infection or injury.
Unfortunately, most people don’t consume enough seafood that contains bioavailable Omega-3 fatty acids to produce sufficient quantities of SPMs. This issue is further exacerbated by environmental pollution and unhealthy dietary habits.
Types of SPMs
When we metabolize omega-3 fatty acids, our body produces various types of SPMs, including:
- Resolvins – Help combat chronic inflammation and protect the brain from oxidative stress.
- Protectins – Studied for their ability to improve insulin resistance and protect the brain and retina from inflammation.
- Maresins – Contribute to tissue regeneration and have potential applications in metabolic health and kidney function.
- Lipoxins – Target cardiovascular and neurological health.
How SPMs Combat Inflammation
Inflammation is a natural response of the body to injuries and infections. However, when inflammation becomes chronic, as seen in autoimmune diseases, it can cause serious health problems.
Instead of completely blocking inflammation, SPMs work by targeting immune cells, helping them calm down and restore balance.
Symptoms of Chronic Inflammation
If you experience any of the following symptoms, you may be suffering from chronic inflammation:
- Chronic pain
- Fluid retention
- Brain fog
- Skin problems such as psoriasis and rashes
- Weight gain
- Insulin resistance
- Cardiovascular diseases
- Nervous system dysfunction
Ways to Reduce Inflammation
In addition to SPMs, reducing inflammation requires a multifaceted approach, such as:
- Healthy diet – Consuming omega-3-rich foods, fruits, vegetables, and anti-inflammatory herbs.
- Mitochondrial support – Mitochondria play a crucial role in cellular energy and inflammation management.
- Reducing exposure to electromagnetic fields (EMFs) – Limiting exposure to artificial radiation may support the body’s natural healing process.
- Grounding – Contact with the Earth (walking barefoot, swimming in the sea) has been shown to reduce inflammation.
SPM Supplement: ROMEGA®
Since most people do not consume enough omega-3 fatty acids, taking a high-quality fish oil supplement containing highly bioavailable marine phospholipids (PL-DHA/EPA) and specialized pro-resolving mediators (SPMs) can be particularly beneficial. ROMEGA® is derived from Arctic Herring caviar and has been confirmed to contain a natural abundance of specialized pro-resolving mediators (SPMs) and their precursors, supporting cellular repair and combating inflammation.
